For this reason, do not use as a supplement while pregnant or breastfeeding.You can build a decent amount of upper body mass that way. Overuse and/or preventative use of DIM is further ill advised because of its hormone altering effects in normal individuals that can result in systemic hormone dysregulation. Excess supplementation may result in skin rashes, increased liver enzymes, as well as nausea and vomiting. A dose of 200 mg was found by a preliminary safety study to be the highest dose that did not produce negative side effects in the research group.ĭIM is considered safe in both food/diet amounts and therapeutic dosages. When supplementing DIM, it is generally taken at between 100 and 200 mg per day. In order to get higher doses, DIM can be supplemented using capsules or combination formulas. It is important that if cooking these vegetables, not to boil them, as it will significantly reduce their beneficial content. This helps to shift the hormonal balance more favourably in men entering andropause ("male menopause").ĭIM can be absorbed directly from eating cruciferous vegetables from the Brassica family, such as cauliflower, cabbage, cress, bok choy, broccoli, kale, and similar green leaf vegetables. As noted above, DIM has been shown to regulate the metabolism of estrogen in the body to be less active. There is a natural balance of the conversion of testosterone to estrogen in the body. Testosterone is one of the hormones responsible for anabolic muscle growth in the body. DIM is likely the first example of a pure androgen receptor blocker extracted from plants.Īs men age, they naturally produce lowered levels of testosterone and over time estrogen can be found in higher concentrations in their tissues, resulting in a loss of muscle mass. It has also been found to reduce PSA expression, and act as a strong competitive inhibitor of dihydrotestosterone (DHT), a hormone responsible for many male-associated problems. Research suggests that DIM preferentially promotes the metabolism of estrogen to the less harmful, and less active 2-hydroxyestrone form.ĭIM has been directly studied as an anti-androgen supplement that can prevent the proliferation of androgen-dependent prostate cancer. In contrast to 2OHE1, 16OHE1 is highly estrogenic and has been found to stimulate the proliferation of several estrogen-sensitive cancer cell lines. This endogenous estrogen can either be metabolized to 16alpha-hydroxyestrone (16OHE1) or 2-hydroxyestrone (2OHE1). It has also been implicated in down-regulating genes required for breast cancer metastasis, although I3C has been studied in far greater detail for this activity.īoth males and females produce estrogen naturally in their bodies, although women produce significantly higher levels. Emerging evidence has shown that exposure of human cancer cells to I3C or DIM triggers transcriptional, cell signaling, enzymatic, and metabolic changes that directly lead to the stoppage of replication and/or apoptosis (regulated cell death). Further research is required to confirm these results before attributing all of the beneficial effects of I3C to DIM.ĭiindolylmethane has been associated with potent anti-cancer effects in several cancers including: lung, liver, colon, cervical, endometrial, prostate, and breast cancer. Recent research has implied that benefits previously attributed to I3C may actually be the result of DIM created through conversion in the digestive tract. This chemical is more shelf-stable and more easily absorbed in the digestive tract than I3C. There is also preliminary research implicating DIM as an immunomodulating supplement against auto-immune disease, although further research is required.ĭIM is a natural diindole condensation product of I3C created during digestion in the presence of sufficient stomach acid. Both I3C and DIM are being examined in clinical trials for their treatment of various types of cancer. Part of this effect is likely due to DIM's role in estrogen metabolism balance in the body (see below). Increased dietary intake of this family of foods has been associated with lowered risk of cancers of all types, particularly those with a hormonal influence on proliferation. DIM is the activated form of I3C whose role in cancer treatment is growing…ĭiindolylmethane (DIM) is a natural condensation product of indole-3-carbinol (I3C), which is found in cruciferous (Brassica family) vegetables such as cauliflower, cabbage, cress, bok choy, broccoli, kale, and similar green leaf vegetables.
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